Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-γc-/- (RAG-hu) mouse model. | BioMed Central Retrovirology Research HIV-1 infection and CD4 T cell depletion in the humanized Rag2- -yc- - RAG-hu mouse model Bradford K Berges1 William H Wheat1 Brent E Palmer2 Elizabeth Connick3 and Ramesh Akkina 1 Open Access Address Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO 80523 USA 2Department of Medicine University of Colorado Health Sciences Center Denver CO 80262 USA and 3Division of Infectious Disease University of Colorado Health Sciences Center Denver CO 80262 USA Email Bradford K Berges - bberges@colostate.edu William H Wheat - wheatw@colostate.edu Brent E Palmer - brent.palmer@uchsc.edu Elizabeth Connick - liz.connick@uchsc.edu Ramesh Akkina - akkina@colostate.edu Corresponding author Published 01 November 2006 Received 20 September 2006 Accepted 01 November 2006 Retrovirology 2006 3 76 doi l0.ll86 l 742-4690-3-76 This article is available from http www.retrovirology.cOm content 3 1 76 2006 Berges et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The currently well-established humanized mouse models namely the hu-PBL-SCID and SCID-hu systems played an important role in HIV pathogenesis studies. However despite many notable successes several limitations still exist. They lack multi-lineage human hematopoiesis and a functional human immune system. These models primarily reflect an acute HIV infection with rapid CD4 T cell loss thus limiting pathogenesis studies to a short-term period. The new humanized Rag2- -Yc- - mouse model RAG-hu created by intrahepatic injection of CD34 hematopoietic stem cells sustains long-term multi-lineage human hematopoiesis
