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The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase (Itk) is predominantly expressed in T cells and has been shown to be critical for the development, function and differentiation of conventional abT cells. However, less is known about its role in nonconventional T cells such as NKT andcdT cells. | ịFEBS Journal MINIREVIEW Tec family kinases Itk signaling and the development of NKT ab and ỴÔ T cells Qian Qi1 2 Arun Kumar Kannan1 2 3 and Avery August1 2 1 Department of Veterinary BiomedicalSciences Center for Molecular Immunology Infectious Disease The Pennsylvania State University University Park PA USA 2 Department of Microbiology Immunology CornellUniversity Ithaca NY USA 3 Immunology Infectious Disease Graduate Program The Pennsylvania State University University Park PA USA Keywords development ERK Id3 Interleukin-4 PLC PLZF SLP-76 signaling T-bet T cell receptor Correspondence A. August Department of Microbiology Immunology C5 171 VMC Cornell University Ithaca NY 14853-6401 USA Fax 1 607 253 3384 Tel 1 607 253 3400 E-mail averyaugust@cornell.edu The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase Itk is predominantly expressed in T cells and has been shown to be critical for the development function and differentiation of conventional ab T cells. However less is known about its role in nonconventional T cells such as NKT and yỗ T cells. In this minireview we discuss evidence for a role for Itk in the development of invariant NKT ab cells as well as a smaller population NKT-like yỗ T cells. We discuss how these cells take what could be the same signaling pathway regulated by Itk and interpret it to give different outcomes with regards to development and function. Note Q. Qi and A. K. Kannan contributed equally to this work Received 31 August 2010 revised 28 October 2010 accepted 25 February 2011 doi 10.1111 j.1742-4658.2011.08074.x Introduction Interleukin-2-inducible T-cell kinase Itk is a member of the Tec family of nonreceptor protein tyrosine kinases which includes Rlk and Tec and is important for effective signaling through the T-cell receptor TCR 1 2 . There are additional Tec family kinases that signal from other receptors and have essential functions in other cell types and these are reviewed in the accompanying minireviews 3 . In
