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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Due caution using early β-blockers for acute myocardial infarction. | This article is online at http ccforum.eom content 11 1 301 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Due caution using early p-blockers for acute myocardial infarction Scott McKee 1 Holt Murray 2 and John A. Kellum3 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Visiting Instructor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 3 Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 25 January 2007 This article is online at http ccforum.com content 11 1 301 2006 BioMed Central Ltd Critical Care 2006 11 301 DOI 101186 cc5145 Expanded Abstract Citation Chen ZM Pan HC Chen YP Peto R Collins R Jiang LX Xie JX Liu LS. Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction randomised placebo-controlled trial. Lancet 2005 366 1622-1632 1 . Background Despite previous randomised trials of early p-blocker therapy in the emergency treatment of myocardial infarction MI uncertainty has persisted about the value of adding it to current standard interventions e.g. aspirin and fibrinolytic therapy and the balance of potential benefits and hazards is still unclear in high-risk patients. Methods Design and setting Prospective blinded randomized controlled trial in 1250 hospitals in China. Subjects 45 852 patients admitted within 24 h of suspected acute MI onset. 93 had ST-segment elevation or bundle branch block and 7 had ST-segment depression. Intervention Subjects were randomly allocated metoprolol up to 15 mg intravenous then 200 mg oral daily n 22 929 or matching placebo n 22 923 . Treatment was to continue until discharge or up to 4 weeks in hospital mean 15 days in survivors and 89 .
