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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Role of PPAR-δ in the development of zymosaninduced multiple organ failure: an experiment mice study. | Galuppo et al. Journal of Inflammation 2010 7 12 http www.journal-inflammation.eom content 7 1 12 JOURNAL OF INFLAMMATION RESEARCH Open Access Role of PPAR-Ỗ in the development of zymosan-induced multiple organ failure an experiment mice study 1Ỷ 2Ỷ 2 - - z 1.2 1 1 Maria Galuppo Rosanna Di Paola Emanuela Mazzon Tiziana Genovese Concetta Crisafulli Irene Paterniti Ị 77r í ra7i2 r i rv. et2 r3 4 jcr iũrrr jrii- 3 4 iTTncroa1 2 Elisabetta Cuzzocrea Placido Bramanti Amar Kapoor Christoph Thiemermann Salvatore Cuzzocrea Abstract Background Peroxisome proliferator-activated receptor PPAR -beta delta is a nuclear receptor transcription factor that regulates gene expression in many important biological processes. It is expressed ubiquitously especially white adipose tissue heart muscle intestine placenta and macrophages but many of its functions are unknown. Saturated and polyunsaturated fatty acids activate PPAR-beta delta but physiological ligands have not yet been identified. In the present study we investigated the anti-inflammatory effects of PPAR-beta delta activation through the use of GW0742 0 3 mg kg 10 Dimethyl sulfoxide DMSO i.p a synthetic high affinity ligand on the development of zymosan-induced multiple organ failure MOF . Methods Multiple organ failure MOF was induced in mice by administration of zymosan given at 500 mg kg i.p. as a suspension in saline . The control groups were treated with vehicle 0.25 ml mouse saline while the pharmacological treatment was the administration of GW0742 0 3 mg kg 10 DMSO i.p. 1 h and 6 h after zymosan administration . MOF and systemic inflammation in mice was assessed 18 hours after administration of zymosan. Results Treatment with GW0742 caused a significant reduction of the peritoneal exudate formation and of the neutrophil infiltration caused by zymosan resulting in a reduction in myeloperoxidase activity. The PPAR-beta delta agonist GW0742 at the dose of 0 3 mg kg in 10 DMSO also attenuated the multiple organ .
