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Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). | Journal of Inflammation BioMed Central Research Inhibition of NF-kB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract Pycnogenol Tanja Grimm1 Zuzana Chovanová2 Jana Muchová2 Katarina Sumegová2 Anna Liptáková2 Zdenka Duracková2 and Petra Hogger 1 Open Access Address 1Institut fur Pharmazie und Lebensmittelchemie Bayerische Julius-Maximilians-Universitat Wurzburg Germany and 2Department of Medical Chemistry Biochemistry and Clinical Biochemistry Faculty of Medicine Comenius University Bratislava Slovak Republic Email Tanja Grimm - hogger@pzlc.uni-wuerzburg.de Zuzana Chovanová - zuzana.chovanova@fmed.uniba.sk Jana Muchová - zdenka.durackova@fmed.uniba.sk Katarina Sumegová - zdenka.durackova@fmed.uniba.sk Anna Liptáková - zdenka.durackova@fmed.uniba.sk Zdenka Duracková - zdenka.durackova@fmed.uniba.sk Petra Hogger - hogger@pzlc.uni-wuerzburg.de Corresponding author Published 27 January 2006 Received 05 November 2005 Accepted 27 January 2006 Journal of Inflammation2006 3 1 doi 10.ll 86 1476-9255-3-1 This article is available from http www.journal-inflammation.cOm content 3 1 1 2006Grimm et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ French maritime pine bark extract Pycnogenol displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven healthy volunteers were obtained before and after five days administration of 200 mg Pycnogenol per day. Plasma samples statistically .