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Báo cáo y học: "Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69. | BioMed Central Respiratory Research Research Open Access Identification of HLA-DRPhep47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlup69 Massimo Amicosante 1 Floriana Berretta1 Milton Rossman2 Richard H Butler3 Paola Rogliani1 Ella van den Berg-Loonen4 and Cesare Saltini1 Address Department of Internal Medicine University of Rome Tor Vergata Rome Italy 2Pulmonary Allergy and Critical Care Division Department of Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA institute of Cell Biology National Research Council Monterotondo Rome Italy and 4Tissue Typing Laboratory University Hospital Maastricht Maastricht The Netherlands Email Massimo Amicosante - amicosan@uniroma2.it FlorianaBerretta-flory_berretta@hotmail.com Milton Rossman - rossmanm@mail.med.upenn.edu Richard H Butler - rbutler@ibc.cnr.it Paola Rogliani - rogliani@uniroma2.it Ella van den Berg-Loonen - evdbl@lwee.azm.nl Cesare Saltini - saltini@med.uniroma2.it Corresponding author Published 14 August 2005 Received 31 March 2005 Respiratory Research 2005 6 94 doi l0.ll86 l465-992l-6-94 Accepted I4 August 2005 This article is available from http respiratory-research.cOm content 6 l 94 2005 Amicosante et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Susceptibility to beryllium Be -hypersensitivity BH has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP P-chain HLA-DPGlu69 and with several HLA-DP -DQ and -DR alleles and polymorphisms. However no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker. Methods In this report we .