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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CCR5Δ32 variant and cardiovascular disease in patients with rheumatoid arthritis: a cohort study. | Rodríguez-Rodríguez et al. Arthritis Research Therapy 2011 13 R133 http arthritis-research.eom content 13 4 R133 RESEARCH ARTICLE Open Access CCR5A32 variant and cardiovascular disease in patients with rheumatoid arthritis a cohort study Luis Rodríguez-Rodríguez1 2t Carlos González-Juanatey3t Mercedes García-Bermúdez1t I m S r D Dcsz l I I 74 I r o ỉ h I ỉ K s I s c I I I z 4 D I KỲ I c V A I 7 CL I I I A r V 72 I Ỉ o r I I vr s 5 I Ỉ o r h I s e f I 1 Tomas R Vázquez-Rodriguez Jose A Miranda-Filloy Benjamin Fernández-Gutiérrez Javier Llorca Javier Martin and Miguel A González-Gay6 Abstract Introduction The aim of our study was to analyze the influence of the CCR5AỈ2 polymorphism in the risk of cardiovascular CV events and subclinical atherosclerosis among patients with rheumatoid arthritis RA . Methods A total of 645 patients fulfilling the American Rheumatism Association 1987 revised classification criteria for RA were studied. Patients were genotyped for the CCR5 rs333 polymorphism using predesigned TaqMan assays. Also HLA DRB1 genotyping was performed using molecular-based methods. Carotid intima-media thickness flow-mediated endothelium-dependent dilatation FMD and endothelium-independent vasodilatation which were used as surrogate markers of subclinical atherosclerosis were measured in a subgroup of patients with no clinical CV disease. Results A lower frequency of carriers of the CCR5A32 allele among patients with CV events 3.4 versus 11.3 P 0.025 odds ratio 0.28 95 confidence interval 95 CI 0.06 to 0.89 was observed. However after adjusting for gender age at time of RA diagnosis and the presence of shared epitope rheumatoid factor and classic CV risk factors in the Cox regression analysis this reduction of CV events in CCR5AỈ2 allele carriers was slightly outside the range of significance P 0.097 hazard ratio 0.37 95 CI 0.12 to 1.19 . Carriers of the CCR5A32 deletion also showed higher FMD values than the remaining patients CCR5 CCR5A32 patients 7.03 6.61 .
