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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects | Journal of Nanobiotechnology BioMed Central Research C60-Fullerenes detection of intracellular photoluminescence and lack of cytotoxic effects Nicole Levi1 2 Roy R Hantgan3 Mark O Lively3 David L Carroll1 and Gaddamanugu L Prasad 4 Open Access Address 1Center for Nanotechnology and Molecular Materials and Department of Physics Wake Forest University Winston-Salem NC 27105 USA 2Virginia Tech and Wake Forest University School of Biomedical Engineering and Sciences Winston-Salem NC 27105 USA 3Department of Biochemistry Wake Forest University Health Sciences Winston-Salem NC 27157 USA and 4Department of General Surgery Wake Forest University Health Sciences Winston-Salem NC 27157 USA Email Nicole Levi - levinh3@wfu.edu Roy R Hantgan - rhantgan@wfubmc.edu Mark O Lively - mlively@wfubmc.edu David L Carroll - carrolldl@wfu.edu Gaddamanugu L Prasad - glprasad@temple.edu Corresponding author Published 14 December 2006 Received II September 2006 . Accepted 14 December 2006 Journal of Nanobiotechnology 2006 4 14 doi 10.1 186 1477-3155-4-14 This article is available from http www.jnanobiotechnology.cOm content 4 1 14 2006 Levi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have developed a new method of application of C60 to cultured cells that does not require water-solubilization techniques. Normal and malignant cells take-up C60 and the inherent photoluminescence of C60 is detected within multiple cell lines. Treatment of cells with up to 200 pg ml 200 ppm of C60 does not alter morphology cytoskeletal organization cell cycle dynamics nor does it inhibit cell proliferation. Our work shows that pristine C60 is non-toxic to the cells and
