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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ. | Available online http arthritis-research.eom content 11 4 R122 Research article Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-Y and counteraction by interferon-Y Hilde Kelchtermans1 Evelien Schurgers1 Lies Geboes1 Tania Mitera1 Jo Van Damme2 Jacques Van Snick3 Catherine Uyttenhove3 and Patrick Matthys1 Laboratories of Immunobiology Rega Institute Faculty of Medicine Katholieke Universiteit Leuven Minderbroedersstraat 10 B-3000 Leuven Belgium 2Molecular Immunology Rega Institute Faculty of Medicine Katholieke Universiteit Leuven Minderbroedersstraat 1 0 B-3000 Leuven Belgium 3Ludwig Institute for Cancer Research Brussels Branch Cellular Genetics and Experimental Units Christian de Duve Institute of Cellular Pathology Université Catholique de Louvain Avenue Hippocrate 75 B-1200 Brussels Belgium Corresponding author Patrick Matthys Patrick.Matthys@rega.kuleuven.be Received 3 Mar 2009 Revisions requested 9 Apr 2009 Revisions received 29 Jul 2009 Accepted 1 7 Aug 2009 Published 1 7 Aug 2009 Arthritis Research Therapy 2009 11 R122 doi 10.11 86 ar2787 This article is online at http arthritis-research.com content 11 4 R122 2009 Kelchtermans et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Interleukin IL -17 is a pro-inflammatory cytokine in rheumatoid arthritis RA and collagen-induced arthritis CIA . Since interferon IFN -Y inhibits Th17 cell development IFN-Y receptor knockout IFN-yR KO mice develop CIA more readily. We took advantage of this model to analyse the mechanisms of action of IL-17 in arthritis. The role of IFN-Y on the effector mechanisms of IL-17 in an in vitro system was also investigated. Methods IFN-yR KO mice induced for CIA