Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus. | Available online http arthritis-research.eom content 10 2 R29 Research article Dysfunctional interferon-a production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus Seung-Ki Kwok1 June-Yong Lee1 2 Se-Ho Park2 Mi-La Cho1 So-Youn Min1 Sung-Hwan Park1 Ho-Youn Kim1 and Young-Gyu Cho1 1 Department of Medicine Division of Rheumatology Center for Rheumatic Diseases and Rheumatism Research Center Catholic Research Institutes of Medical Sciences Catholic University of Korea Banpo-Dong Seocho-Gu Seoul 137-701 Korea 2School of Life Sciences and Biotechnology Korea University Anam-Dong Seongbuk-Gu Seoul 136-701 Korea Contributed equally Corresponding author Ho-Youn Kim ho091 9@catholic.ac.krYoung-Gyu Cho younggyuch0@catholic.ac.kr Received 9 Oct 2007 Revisions requested 6 Nov 2007 Revisions received 19 Feb 2008 Accepted 6 Mar 2008 Published 6 Mar 2008 Arthritis Research Therapy 2008 10 R29 doi 10.1186 ar2382 This article is online at http arthritis-research.com content 10 2 R29 2008 Kwok et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background It is well known that interferon IFN -a is important to the pathogenesis of systemic lupus erythematosus SLE . However several reports have indicated that the number of IFN-a producing cells are decreased or that their function is defective in patients with SLE. We studied the function of plasmacytoid dendritic cells pDCs under persistent stimulation of Toll-like receptor TLR 9 via a TLR9 ligand CpG ODN2216 or SLE serum. Methods The concentrations of IFN-a were determined in serum and culture supernatant of peripheral blood mononuclear cells PBMCs from SLE patients and healthy controls .
