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RNomics is a newly emerging sub-discipline of genomics that categorically studies the structure, function and processes of non-coding ribo nucleic acids in a cell. MicroRNomics is a sub-field of RNomics that describes the biogenesis and mechanisms of tiny RNA regulators, and their involvement in the processes of development, differentiation, cell proliferation, cell death, chromosomal segregation and metabolism. The discovery of microRNAs in species ranging from Caenorhabditis elegans (C. elegans) to humans, and their regulatory functions, opened a new tier of understanding of gene expression. In addition, the study of RNA interference (RNAi) and its mechanisms propelled the elucidation of various functions of microRNAs. The development and brisk progress in. | MicroRNAS From Basic science to Disease Biology Edited by Krishnarao Appasani Sidney AJtman and Vkwr R.Amkos This page intentionally left blank MicroRNAs MicroRNAs miRNAs are evolutionary conserved RNA molecules that regulate gene expression and their recent discovery is currently revolutionizing both basic biomedical research and drug discovery. Expression levels of miRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work written by leading experts from both academia and industry will be an invaluable resource for all those wishing to use miRNA techniques in their own research from graduate students post-docs and researchers in academia to those working in research and development in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology this volume uniquely integrates the basic science with industry application towards drug validation diagnostic and therapeutic development. Krishnarao Appasani is the Founder and Chief Executive Officer of Gene Expression Systems a gene discovery company focusing on functional genomics in cancer research. He is the Editor of RNA Interference From Basic Science to Drug Development 2005
