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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus. | Available online http arthritis-research.eom content 6 2 R129 Research article Open Access Decreased levels of soluble amyloid p-protein precursor and p-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus Estelle Trysberg1 Kina Hoglund2 Elisabet Svenungsson3 Kaj Blennow2 and Andrej Tarkowski1 Department of Rheumatology and Inflammation Research Goteborg University Sahlgrenska University Hospital Goteborg Sweden institute of Clinical Neuroscience Goteborg University Sahlgrenska University Hospital Goteborg Sweden 3Department of Rheumatology and Center for Molecular Medicine Karolinska Hospital Stockholm Sweden Correspondence Estelle Trysberg e-mail estelle@immuno.gu.se Received 24 Nov 2003 Revisions requested 18 Dec 2003 Revisions received 22 Dec 2003 Accepted 7 Jan 2004 Published 22 Jan 2004 Arthritis Res Ther 2004 6 R129-R136 DOI 10.1186 ar1040 2004 Trysberg et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Symptoms originating from the central nervous system CNS frequently occur in patients with systemic lupus erythematosus SLE . These symptoms are extremely diverse including a state of dementia. The aim of this study was to examine the cerebrospinal fluid CSF content of soluble molecules indicating axonal degeneration and amyloidogenesis. One hundred and fourteen patients with SLE and age-matched controls were evaluated clinically with magnetic resonance imaging of the brain and CSF analyses. Levels of tau amyloid precursor protein APP p-amyloid protein Ap42 and transforming growth factor beta TGF-p were all determined using sandwich ELISAs. APP and Ap42 levels were significantly decreased in SLE patients irrespective of their CNS involvement as compared with healthy controls. Patients with .
