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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Maitake Mushroom Extracts Ameliorate Progressive Hypertension and Other Chronic Metabolic Perturbations in Aging Female Rats. | Int. J. Med. Sci. 2010 7 169 International Journal of Medical Sciences 2010 7 4 169-180 Ivyspring International Publisher. All rights reserved Research Paper Maitake Mushroom Extracts Ameliorate Progressive Hypertension and Other Chronic Metabolic Perturbations in Aging Female Rats Harry G. Preuss13 Bobby Echard1 Debasis Bagchi2 Nicholas V. Perricone3 1. Georgetown University Medical Center Department of Physiology Washington D.C. 20057 USA 2. University of Houston College of Pharmacy Department of Pharmacological and Pharmaceutical Services Houston TX 77204 USA 3. Michigan State University College of Human Medicine East Lansing MI 48824-136 USA H Corresponding author Harry G. Preuss M.D. M.A.C.N. C.N.S. Professor of Physiology Medicine Pathology Georgetown University Medical Center Basic Science Building Room 231 B 4000 Reservoir Road NW Washington D.C. 20057. Work Phone 202-687-1441 Work Fax 202-687-8788 E mail preusshg@georgetown.edu Received 2010.03.17 Accepted 2010.06.04 Published 2010.06.07 Abstract Objective We assessed the ability of two commercially-available fractions labeled SX and D derived from the edible maitake mushroom to overcome many age-associated metabolic perturbations such as progressive age-related elevation of blood pressure over activity of the renin-angiotensin system RAS decreased insulin sensitivity and inflammation in an in vivo laboratory model. Design and Method We divided forty mature female Sprague-Dawley rats SD into five groups of eight. SD ingested regular rat chow containing added sucrose 20 w w . The groups received baseline diet alone control or baseline diet containing captopril niacin-bound chromium maitake fraction SX or maitake fraction D. In addition to blood pressure readings the following procedures were implemented losartan and insulin challenges evaluation of serum ACE activity glucose tolerance testing blood chemistries LNAME challenge and measurement of various circulating cytokines. Results We found that .
