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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Molecular characterization and complete genome sequence of avian paramyxovirus type 4 prototype strain duck/Hong Kong/D3/75 | Virology Journal BioMed Central Open Access Molecular characterization and complete genome sequence of avian paramyxovirus type 4 prototype strain duck Hong Kong D3 75 Baibaswata Nayak1 Sachin Kumar1 Peter L Collins2 and Siba K Samal 1 Address 1Virginia-Maryland Regional College of Veterinary Medicine University of Maryland College Park Maryland USA and laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases Bethesda USA Email Baibaswata Nayak - bnayak@umd.edu Sachin Kumar - sachin22@umd.edu Peter L Collins - pcollins@niaid.nih.gov Siba K Samal - ssamal@umd.edu Corresponding author Published 20 October 2008 Received 15 September 2008 Accepted 20 October 2008 Virology Journal 2008 5 124 doi l0.ll86 l743-422X-5-l24 This article is available from http www.virologyj.com content 5 l l24 2008 Nayak et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Avian paramyxoviruses APMVs are frequently isolated from domestic and wild birds throughout the world. All APMVs except avian metapneumovirus are classified in the genus Avulavirus of the family Paramyxoviridae. At present the APMVs of genus Avulavirus are divided into nine serological types APMV l-9 . Newcastle disease virus represents APMV-l and is the most characterized among all APMV types. Very little is known about the molecular characteristics and pathogenicity of APMV 2-9. Results As a first step towards understanding the molecular genetics and pathogenicity of APMV-4 we have sequenced the complete genome of APMV-4 strain duck Hong Kong D3 75 and determined its pathogenicity in embryonated chicken eggs. The genome of APMV-4 is l5 054 nucleotides nt in length which is consistent with the rule of six . The genome contains six
