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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company | Gargouri et al. Journal of Occupational Medicine and Toxicology 2011 6 28 http www.occup-med.eom content 6 1 28 _ JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company 1.2.3 12 2 3 2 Imed Gargouri Moncef Khadhraoui Catherine Nisse Ariane Leroyer Mohamed L Masmoudi Paul Frimat Daniel Marzin2 Boubaker Elleuch 1 and Denis Zmirou-Navier4 5 6 Abstract Objectives to assess environmental and biological monitoring of exposure to organic solvents in a gluemanufacturing company in Sfax Tunisia. Methods Exposure of volunteer workers in the solvented glue-work-stations in the control laboratory and in the storage rooms of the finished products was assessed through indoor-air and urine measurements. Informed consent of the workers was obtained. Results and discussion The exposure indexes were found with high values in the solvented workshop as well as in the control laboratory and were respectively 8.40 and 3.12. These indexes were also correlated with hexane and toluene indoor air concentrations. As to urine the obtained results for the 2 5-hexandione and hippuric acid metabolites of hexane and toluene respectively were in accord with the indoor-air measurements with an average of 0.46 mg l and 1240 mg g of creatinine. Conclusion This study assessed for the first time biological exposure to organic solvents used in Tunisian adhesive industries. Although values are likely to underestimate true exposure levels some figures exceed European and American occupational exposure guidelines. Keywords Adhesive manufacturing Organic solvents Hexane Bio-monitoring Occupational exposure assessment Introduction Organic solvents are a group of mainly volatile compounds widely used to dissolve other substances in industrial processes among them adhesive manufacturing ones. Through their handling these solvents can be released into the environment during production storage .
