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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Linkage disequilibrium in French of Drosophila melanogaster | Genet. Sei. Evol. 1989 21 33-47 Elsevier INRA 33 Original article Linkage disequilibrium in French natural populations of Drosophila melanogaster J. Sanchez Prado 1 L. Charles-Palabost2 M. Katz3 and A. Merẹot 4 1 Universidadde Oviedo Departamento de Genetica Asturias Spain 2 Université F. Rabelais IBEAS avenue Monge Parc Grandmont 37200 Tours France 3 Université de Paris VII Laboratoire de Génétique Quantitative et Moléculaire and 4 Université de Paris VII Laboratoire de Génétique des Populations Tour 42-32 2 place Jussieu 75005 Paris France received 23-9-1987 accepted 25-4-1988 Summary Seventeen French natural populations of Drosophila melanogaster were analyzed to detect linkage disequilibrium between pairs of 6 polymorphic allozyme loci. The estimates of linkage disequilibrium were made from azygotic frequencies using both Burrows and Hills s methods No difference between these 2 methods was found. The amount of significant linkage disequilibrium detected was small and similar to those in other natural populations of D. melanogaster. Out of the 15 combinations examined only 2 pairs Adh-a-Gpdh and Est-C-Est-6 showed a consistent significant linkage disequilibrium in the populations studied. However for the first pair the result was probably due to an association between the loci and the inversion 2 L t of the second chromosome. For the Est-C-Est-6 pair the disequilibrium detected might result from an interaction effect between the 2 genes inter se. These results again show the difficulties in detecting linkage disequilibrium due to epistasis between allozyme genes in natural populations. Drosophila melanogaster - linkage disequilibrium - enzymatic loci - French natural populations Résumé Déséquilibre de liaison dans des populations naturelles frangaises de Drosophila melanogaster. Une analyse du déséquilibre de liaison a été ettectuée pour 6 locus enzymatiques dans 17 populations naturelles de Drosophila melanogaster. Les estimations de ce déséquilibre out été .
