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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin, tilmicosin, and enrofloxacin | J. Vet. Set. 2006 7 4 355-359 JOURNAL OF Veterinary Science In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin tilmicosin and enrofloxacin Doo Kim1 2 Dorsey Kordick3 Thomas Divers1 Yung-Fu Chang1 1 College of Veterinary Medicine Cornell University Ithaca NY 14853 USA department of Veterinary Medicine Kangwon National University Chunchon 200-701 Korea 3IDEXXLaboratories Greensboro NC 27410 USA Antimicrobial susceptibility testing was conducted with 6 different spirochetal strains 4 strains of Leptospira spp. and 2 strains ữĩBorrelia burgdorferi against 3 antimicrobial agents commonly used in equine and bovine practice. The ranges of MIC and MBC of amoxicillin against Leptospira spp. were 0.05-6.25 pg ml and 6.25-25.0 pg ml respectively. And the ranges of minimal inhibitory concentration MIC and minimal bactericidal concentration MBC of amoxicillin against B. burgdorferi were 0.05-0.39 pg ml and 0.20-0.78 pg ml respectively. The ranges of MIC and MBC of enrofloxacin against Leptospira spp. were 0.050.39 pg ml and 0.05-0.39 pg ml respectively. Two strains of B. burgdorferi were resistant to enrofloxacin at the highest concentration tested for MBC 100 pg ml . Therefore the potential role of tihnicosin in the treatment of leptospirosis and borreliosis should be further evaluated in animal models to understand whether the in vivo studies will confirm in vitro results. All spirochetal isolates were inhibited MIC and were killed MBC by tihnicosin at concentrations below the limit of testing 0.01 pg ml . Key words amoxicillin antibiotics Borrelia burgdorferi enrofloxacin Leptospira spp. susceptibility tilmicosin Introduction Leptospirosis is a zoonotic infection with a worldwide distribution that is associated with both endemic disease and epidemics with the incidence of disease being highest in tropical climates 17 . The number of cases of leptospfrosis diagnosed has increased since 1983 in North America 36 . Lyme disease is a .
