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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Estimation by simulation of the efficiency of the French marker-assisted selection program in dairy cattle (Open Access publication) | Genet. Sel. Evol. 40 2008 91-102 INRA EDP Sciences 2008 DOI 10.1051 gse 2007036 Available online at www.gse-journal.org Original article Estimation by simulation of the efficiency of the French marker-assisted selection program in dairy cattle Open Access publication Francois Guillaume1 2 Sébastien FRITZ3 Didier BOICHARD1 Tom DRUET1 1INRA UR337 Station de génétique quantitative et appliquée 78350 Jouy-en-Josas France 2 Institut de l élevage 149 rue de Bercy 75595 Paris Cedex 12 France 3 Union nationale des coopératives d élevage et d insémination animale 149 rue de Bercy 75595 Paris Cedex 12 France Received 19 January 2007 accepted 3 September 2007 Abstract - The efficiency of the French marker-assisted selection MAS was estimated by a simulation study. The data files of two different time periods were used April 2004 and 2006. The simulation method used the structure of the existing French MAS same pedigree same marker genotypes and same animals with records.The program simulated breeding values and new records based on this existing structure and knowledge on the QTL used in MAS variance and frequency . Reliabilities of genetic values of young animals less than one year old obtained with and without marker information were compared to assess the efficiency of MAS for evaluation of milk fat and protein yields and fat and protein contents. Mean gains of reliability ranged from 0.015 to 0.094 and from 0.038 to 0.114 in 2004 and 2006 respectively. The larger number of animals genotyped and the use of a new set of genetic markers can explain the improvement of MAS reliability from 2004 to 2006. This improvement was also observed by analysis of information content for young candidates. The gain of MAS reliability with respect to classical selection was larger for sons of sires with genotyped progeny daughters with records. Finally it was shown that when superiority of MAS over classical selection was estimated with daughter yield deviations obtained after progeny test
