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Bond, JA Chuyển hóa và thải trừ của thuốc hít vào và hóa chất trong không khí từ phổi. Pharmacol. Toxicol. 72: 36-47, 1993. Cho, M., Chichester C., C. Plopper, và A. Buckpitt. Các yếu tố sinh hóa quan trọng trong Clara tế bào độc tính chọn lọc trong phổi. Thuốc Metabol | SUGGESTED READING 325 SUGGESTED READING Bond J. A. Metabolism and elimination of inhaled drugs and airborne chemicals from the lungs. Pharmacol. Toxicol. 72 36-47 1993. Cho M. C. Chichester C. Plopper and A. Buckpitt. Biochemical factors important in Clara cell selective toxicity in the lung. Drug Metabol. Rev. 27 369-386 1995. Dahl A. R. and J. L. Lewis. Respiratory tract uptake of inhalants and metabolism of xenobi-otics. An. Rev. Pharmacol. Toxicol. 32 383-407 1993. Foth H. Role of the lung in accumulation and metabolism of xenobiotic compounds-implications for chemically induced toxicity. Crit. Rev. Toxicol. 25 165-205 1995. Henderson R. J. and K. J. Nikula. Respiratory tract toxicity. In Introduction to Biochemical Toxicology 3rd ed. E. Hodgson and R. C. Smart eds. New York Wiley-Interscience 2001. Wheeler C. W. T. M. Guenthner. Cytochrome P450-dependent metabolism of xenobiotics in human lung. J. Biochem. Toxicol. 6 163-169 1991. Witschi H. R. and J. A. Last. Toxic responses of the respiratory system. In Casarett andDoull s Toxicology The Science of Poisons 6th ed. C. D. Klaassen ed. New York McGraw-Hill 2001 pp. 515-534. CHAPTER 19 Immunotoxicity MARYJANE K. SELGRADE 19.1 INTRODUCTION A properly functioning immune system is essential to good health. It defends the body against infectious agents and in some cases tumor cells. Individuals with immune deficiencies resulting from genetic defects diseases e.g. AIDS leukemia or drug therapies are more susceptible to infections and certain types of cancer the consequences of which can be life-threatening. On the other hand the immune system may react to foreign substances that would otherwise be relatively innocuous such as certain chemicals pollens and house dust. The resulting allergic reactions can produce an array of pathologies ranging from skin rashes and rhinitis to more life-threatening asthmatic and anaphylactic reactions. A crucial part of immune function is the ability to distinguish endogenous .
