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Việc điều trị nên bắt đầu trên cơ sở cl inical trong quan điểm của các mức độ nghiêm trọng của nhiễm độc và thời gian thực hiện cho phòng thí nghiệm xác nhận. Làm rỗng dạ dày khẩn cấp là thứ wi requi đỏ insti llation nước 500ml có chứa 150g Ful Ler của trái đất và 25g | Morphine 10mg IM SC 4-hrly 5-20mg PO 4-hrly Codeine 30-60mg IM 4-hrly 30-60mg PO 4-hrly Diamorphine 5mg IM SC 4-hrly 5-10mg PO 4-hrly Dihydrocodeine 50mg IM SC 4-6-hrly 30mg PO 4-6-hrly Pethidine 25-100mg IM SC 4-hrly 50-150mg PO 4-hrly Note that the above doses are a guide only and may need to be altered widely according to individual circumstances. The correct dose of an opiate analgesic is generally enough to ablate pain. See also IPPV failure to tolerate ventilation p12 Non-opioid analgesics p236 Sedatives p238 Pain p532 Post-operative intensive care p534 P.236 Non-opioid analgesics Types Non-steroidal anti-inflammatory drugs e.g. aspirin indomethacin diclofenac Paracetamol Ketamine Nitrous oxide Local anaesthetics e.g. lidocaine bupivacaine Uses Pain associated with inflammatory conditions aspirin indomethacin diclofenac Post-operative pain and musculoskeletal pain aspirin indomethacin diclofenac paracetamol ketamine nitrous oxide lidocaine bupivacaine Opiate sparing effect aspirin indomethacin diclofenac used with strong analgesics Antipyretic aspirin paracetamol Routes IV ketamine IM diclofenac PO aspirin indomethacin diclofenac paracetamol PR aspirin diclofenac paracetamol Local regional lidocaine bupivacaine Inhaled nitrous oxide Side-effects Gastrointestinal bleeding aspirin indomethacin diclofenac Renal dysfunction indomethacin diclofenac if any hypovolaemia Reduced platelet aggregation aspirin indomethacin diclofenac Reduced prothrombin formation aspirin indomethacin diclofenac Myocardial depression lidocaine bupivacaine Hypertension and tachycardia ketamine Seizures lidocaine bupivacaine Hallucinations and psychotic tendencies ketamine prevented by concurrent use of benzodiazepines or droperidol Notes Paracetamol overdose can cause severe hepatic failure due to the effects of alkylating metabolites. Though normally removed by conjugation with glutathione stores are rapidly depleted in overdose. Non-steroidal anti-inflammatory agents should be .