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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes . | Research Open Access Molecular signature of hypersaline adaptation insights from genome and proteome composition of halophilic prokaryotes Sandip Paul Sumit K Bag Sabyasachi Das Eric T Harvill and Chitra Dutta Addresses Bioinformatics Center Indian Institute of Chemical Biology 4 Raja SC Mullick Road Kolkata - 700 032 India. Department of Biology The Pennsylvania State University Mueller Lab University Park PA 16802 USA. Department of Veterinary and Biomedical Sciences The Pennsylvania State University University Park PA 16802 USA. Structural Biology and Bioinformatics Division Indian Institute of Chemical Biology 4 Raja SC Mullick Road Kolkata - 700 032 India. Correspondence Chitra Dutta. Email cdutta@iicb.res.in Published 9 April 2008 Genome Biology 2008 9 R70 doi 10.1 186 gb-2008-9-4-r70 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 4 R70 Received 13 March 2008 Revised 1 April 2008 Accepted 9 April 2008 2008 Paul et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Halophilic prokaryotes are adapted to thrive in extreme conditions of salinity. Identification and analysis of distinct macromolecular characteristics of halophiles provide insight into the factors responsible for their adaptation to high-salt environments. The current report presents an extensive and systematic comparative analysis of genome and proteome composition of halophilic and non-halophilic microorganisms with a view to identify such macromolecular signatures of haloadaptation. Results Comparative analysis of the genomes and proteomes of halophiles and non-halophiles reveals some common trends in halophiles that transcend the boundary of phylogenetic .
