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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Monocyte TREM-1 membrane expression in non-infectious inflammation. | Available online http ccforum.eom content 13 3 152 Commentary Monocyte TREM-1 membrane expression in non-infectious inflammation Jean-Marc Cavaillon Unit Cytokines Inflammation Institut Pasteur 28 rue Dr Roux 75015 Paris France Corresponding author Jean-Marc Cavaillon jean-marc.cavaillon@pasteur.fr Published 1 June 2009 This article is online at http ccforum.com content 13 3 152 2009 BioMed Central Ltd Critical Care 2009 13 152 doi 10.1186 cc7882 See related research by Ferat-Osorio et al. http ccforum.com content 13 3 R69 Abstract Sterile or non-infectious inflammation and severe infection are accompanied by very similar events. Damage or danger -associated molecular patterns and pathogen-associated molecular patterns trigger the release of inflammatory mediators and modulate the expression of cell surface receptors. The increased expression on monocytes and neutrophils of triggering receptor expressed on myeloid cells 1 is a hallmark of both infectious and non-infectious inflammation. The report by Isibasi s team published in the present issue of Critical Care shows that the enhanced expression of triggering receptor expressed on myeloid cells 1 TREM-1 on circulating monocytes in patients with acute pancreatitis is independent of the occurrence of infection 1 . This study further illustrates the difficulty of defining soluble or cell surface markers that would allow delimiting a neat border between infection and sterile or non-infectious inflammation. The recently characterized damage or danger -associated molecular patterns that emerged from the theory of danger model proposed by Matzinger 2 and the pathogen-associated molecular patterns that came to light after the revised definition of innate immunity by Janeway 3 are the key elements that unify infectious and non-infectious inflammation. Indeed the fact that the same Toll-like receptors TLRs and NOD-like receptors recognize both damage or danger -associated molecular patterns and pathogen-associated molecular
