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Báo cáo y học: "The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study. | Available online http ccforum.eom content 13 3 R67 Open Access Research The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill a randomised double-blind placebo-controlled cross over study Adam M Deane1 2 Marianne J Chapman1 2 Robert JL Fraser3 4 Carly M Burgstad5 Laura K Besanko3 and Michael Horowitz4 University of Adelaide Discipline of Anaesthesia and Intensive Care North Terrace Adelaide 5000 South Australia Australia 2Royal Adelaide Hospital Department of Intensive Care North Terrace Adelaide 5000 South Australia Australia investigation and Procedures Unit Repatriation General Hospital Daws Road Daw Park 5041 South Australia Australia 4University of Adelaide Discipline of Medicine North Terrace Adelaide 5000 South Australia Australia 5Royal Adelaide Hospital Department of Gastroenterology North Terrace Adelaide 5000 South Australia Australia Corresponding author Adam M Deane adam.deane@adelaide.edu.au Received 10 Feb 2009 Revisions requested 11 Mar 2009 Revisions received 24 Mar 2009 Accepted 13 May 2009 Published 13 May 2009 Critical Care 2009 13 R67 doi 10.1186 cc7874 This article is online at http ccforum.com content 13 3 R67 2009 Deane et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Hyperglycaemia occurs frequently in the critically ill affects outcome adversely and is exacerbated by enteral feeding. Furthermore treatment with insulin in this group is frequently complicated by hypoglycaemia. In healthy patients and those with type 2 diabetes exogenous glucagon-like peptide-1 GLP-1 decreases blood glucose by suppressing glucagon stimulating insulin and slowing gastric emptying. Because the former effects are .