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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-β1 gene. | BioMed Central Comparative Hepatology Research Open Access Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-p1 gene Kun-Lin Yang1 Kuo-Chen Hung2 Wen-Teng Chang3 and Eric IC Li 4 Address 1Institute of Basic Medical Sciences College of Medicine National Cheng Kung University Tainan 701 Taiwan 2Department of General Surgery E-DA Hospital I-Shou University Kaohsiung 824 Taiwan 3Department of Biological Science and Technology Chung Hwa University of Medical Technology Tainan 717 Taiwan and 4Department of Pharmacology College of Medicine National Cheng Kung University Tainan 701 Taiwan Email Kun-Lin Yang - s5889103@ccmail.ncku.edu.tw Kuo-Chen Hung - hcc4723@yahoo.com.tw Wen- Teng Chang - wtchang@mail.hwai.edu.tw Eric IC Li - ericli@mail.ncku.edu.tw Corresponding author Published 19 October 2007 Received 22 May 2007 tn Jm I Z I.1 r z z z Accepted 19 October 2007 Comparative Hepatology 2007 6 9 doi l0.ll 86 1476-5926-6-9 r This article is available from http www.comparative-hepatology.com content 6 1 9 2007 Yang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Liver fibrosis represents a significant and severe health care problem and there are no efficient drugs for therapy so far. Preventing the progression of fibrogenesis and revival endogenous repair activities is an important strategy for both current and future therapies. Many studies of liver fibrosis consist of animal testing with various hepatotoxins. Although this method is often used the model at which cirrhosis or extensive fibrosis becomes irreversible has not been well defined and is not representative of early-stage fibrogenesis. We here report the establishment of a transient and reversible liver .
