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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or apoptosis in hepatic stellate cells. | Comparative Hepatology BioMed Central Open Access Endothelin-I enhances fibrogenic gene expression but does not promote DNA synthesis or apoptosis in hepatic stellate cells Masahiko Koda 1 2 Michael Bauer1 Anja Krebs1 Eckhart G Hahn1 Detlef Schuppan1 3 and Yoshikazu Murawaki2 Address 1First Department of Medicine University of Erlangen-Nuernberg Erlangen Germany 2Second Department of Internal Medicine Faculty of Medicine Tottori University Yonago 683-8504 Japan and 3Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA Email Masahiko Koda - masakoda@grape.med.tottori-u.ac.jp Michael Bauer - michael.bauer@chir.imed.uni-erlangen.de Anja Krebs - Anja.Krebs@med1.imed.uni-erlangen.de Eckhart G Hahn - eckhart.hahn@med1.imed.uni-erlangen.de Detlef Schuppan - dschuppa@bidmc.harvard.edu Yoshikazu Murawaki - murawaki@grape.med.tottori-u.ac.jp Corresponding author Published 24 October 2006 Received 01 March 2006 _ _ . . .- m- r r Accepted 24 October 2006 Comparative Hepatology 2006 5 5 doi l0.ll86 l476-5926-5-5 This article is available from http www.comparative-hepatology.com content 5 1 5 2006 Koda et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In liver injury the pool of hepatic stellate cell HSC increases and produces extracellular matrix proteins decreasing during the resolution of fibrosis. The profibrogenic role of endothelin-l ET-l in liver fibrosis remains disputed. We therefore studied the effect of ET-l on proliferation apoptosis and profibrogenic gene expression of HSCs. Results First passage HSC predominantly expressed endothelin A receptor ETAR mRNA
