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Fractions yielded from Phellinus gilvus fruiting bodies by liquid-liquid partition of methanol extract contained various bioactive compounds such as phenolics, flavonoids and terpenes. Butanol, water and ethyl acetate fractions had large amount of phenolics, 158.12 - 247.31 mg of gallic acid equivalents (GAE)/g and low amount of flavonoids, 21.74 - 36.05 mg of quercetin equivalents (QE)/g. | VNU Journal of Science Natural Sciences and Technology Vol. 38 No. 1 2022 82-90 Original Article Total Phenolic Flavonoid Content and Antioxidative α-amylase Inhibitory Activity of Phellinus gilvus Fruiting Body Extracts Duong Thi Hong Dang Ngoc Quang Hanoi National University of Education 136 Xuan Thuy Cau Giay Hanoi Vietnam Received 02 December 2020 Revised 19 February 2021 Accepted 29 August 2021 Abstract Fractions yielded from Phellinus gilvus fruiting bodies by liquid-liquid partition of methanol extract contained various bioactive compounds such as phenolics flavonoids and terpenes. Butanol water and ethyl acetate fractions had large amount of phenolics 158.12 - 247.31 mg of gallic acid equivalents GAE g and low amount of flavonoids 21.74 - 36.05 mg of quercetin equivalents QE g. These values highly correlated with their antioxidative activity including 1 1-diphenyl-2-picrylhydrazyl DPPH scavenging potential with IC50 values of 84.5 -108.44 μg mL and reducing power. These fractions showed moderate α-amylase inhibitory activity with IC50 values of 4.77 10.69 and 3.9 mg mL respectively. P. gilvus fractions exhibited negligible inhibitory activity on the growth of tested Gram-positive and Gram-negative bacterial strains at the concentration of 20 mg mL. The results suggest the utility of butanol water and ethyl acetate fractions from fruiting bodies of P. gilvus collected in Vietnam for further characterization in order to apply for diabetes or anti-aging prevention. Keywords Phellinus gilvus antioxidative activity α-amylase inhibition. 1. Introduction P. linteus P. baumii and P. nigricans 3 are well known for representing an unlimited Mushrooms have recently become a potent source of antitumor or immuno-stimulating candidate for functional foods because of their anti-inflammatory polysaccharides 4 5 and high contents of protein crude fiber minerals anti-inflammatory phenolic metabolites 6 . and vitamins 1 as well as physiologically Phellinus species have .
