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Expression of AE1/p16 promoted degradation of AE2 in gastric cancer cells

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Human anion exchanger 1 and 2 (AE1 and AE2) mediate the exchange of Cl− /HCO3 − across the plasma membrane and regulate intracellular pH (pHi). AE1 is specifically expressed on the surface of erythrocytes, while AE2 is widely expressed in most tissues, and is particularly abundant in parietal cells. |

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