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For loco-regionally advanced, but transorally resectable oropharyngeal cancer (OPSCC), the current standard of care includes surgical resection and risk-adapted adjuvant (chemo) radiotherapy, or definite chemoradiation with or without salvage surgery. | Comparative effectiveness trial of transoral head and neck surgery followed by adjuvant radio chemo therapy versus primary radiochemotherapy for oropharyngeal cancer TopROC