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Patients with locally advanced bladder cancer (cT3/4 cN0/N+ cM0) have a poor prognosis despite radical surgical therapy and perioperative chemotherapy. Preliminary data suggest that the combination of radiation and immunotherapy does not lead to excess toxicity and may have synergistic (abscopal) anti-tumor effects. | Radiation therapy before radical cystectomy combined with immunotherapy in locally advanced bladder cancer study protocol of a prospective single arm multicenter phase II trial RACE IT