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This study introduced a method to produce a thermosensitive nanocomposite hydrogel (nCur-PG) containing curcumin nanoparticles (nCur) which can overcome the poor dissolution of curcumin. Regarding to the method, a thermo-reversible pluronic F127-grafted gelatin (PG) play a role as surfactant to disperse and protect nanocurcumin from aggregation. The synthetic PG was identified by 1H-NMR. The obtained results via Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS) indicated that the size of nCur was various in the range from 1.5 ± 0.5 to 128 ± 9.7 nm belong to amount of the fed curcurmin. | Thermosensitive nanocomposite hydrogel based pluronic-grafted gelatin and nanocurcumin for enhancing burn healing 146 SCIENCE AND TECHNOLOGY DEVELOPMENT JOURNAL: NATURAL SCIENCES, VOL 2, ISSUE 4, 2018 Thermosensitive nanocomposite hydrogel based pluronic-grafted gelatin and nanocurcumin for enhancing burn healing Huynh Thi Ngoc Trinh, Nguyen Tien Thinh, Ha Le Bao Tran, Vu Nguyen Doan, Tran Ngoc Quyen Abstract—Curcumin is extracted from turmeric exhibiting several biomedical activities. 1 INTRODUCTION Unfortunately, less aqueous solubility was still a drawback to apply it in medicine. This study introduced a method to produce a thermosensitive R ecent years, exploitation of naturally bioactive compounds has paid much attention in medicine due to their broad-spectrum nanocomposite hydrogel (nCur-PG) containing curcumin nanoparticles (nCur) which can overcome bioactivity such as anti-inflammation, anti- the poor dissolution of curcumin. Regarding to the oxidation, anticancer, wound healing and etc [1]. method, a thermo-reversible pluronic F127-grafted Among of them, curcumin (1,7-bis (4-hydroxy- gelatin (PG) play a role as surfactant to disperse and 3-methoxyphenyl)- 1,6-heptadiene-3,5-dione) protect nanocurcumin from aggregation. The isolated from rhizome of Curcuma longa plant synthetic PG was identified by 1H-NMR. The exhibiting desirable pharmaceutical properties obtained results via Transmission Electron including anti-inflammatory [2-3], antioxidant Microscopy (TEM) and Dynamic Light Scattering [4-5], anti-tumor [6], anti-HIV [7], anti- (DLS) indicated that the size of nCur was various in the range from 1.5 ± 0.5 to 128 ± 9.7 nm belong to microbial activity [8-9], and wound healing amount of the fed curcurmin. The nCur-dispersed agent [10]. Despite its attractive pharmaceutical PG solution formed nCur-PG when the solution was characteristics, low aqueous solubility, poor warmed up to 34-35 oC. Release profile
