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Four megastigmans 7-megastigmene-3-ol-9-one 3-O-[α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside] (1), alangionoside L (2), alangioside (3), ampelopsisionoside (4), and other constituents as N–trans-feruloyloctopamide (5), trans-linalool-3,6-oxide-β-D-glucopyranoside (6), 5α,8α-dipioxiergosta-6,22-diene-3β-ol (7), and (Z)-2-hexenyl β-Dglucopyranoside (8) were isolated from the methanol extract of the Antidesma hainanensis leaves. Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported data. This is the first report of these compounds from Euphorbiaceae family. | Vietnam Journal of Chemistry, International Edition, 54(6): 678-682, 2016 DOI: 10.15625/0866-7144.2016-00386 Megastigmans and other compounds from Antidesma hainanensis Merr. Le Canh Viet Cuong1, Do Thi Trang1, Nguyen Xuan Nhiem1, Pham Hai Yen1, Bui Huu Tai1, Hoang Le Tuan Anh1, Le Mai Huong2, Chau Van Minh1, Phan Van Kiem1* 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 2 Institute of Natural Products Chemistry, VAST Received 28 June 2016; Accepted for publication 8 December 2016 Abstract Four megastigmans 7-megastigmene-3-ol-9-one 3-O-[α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside] (1), alangionoside L (2), alangioside (3), ampelopsisionoside (4), and other constituents as N–trans-feruloyloctopamide (5), trans-linalool-3,6-oxide-β-D-glucopyranoside (6), 5α,8α-dipioxiergosta-6,22-diene-3β-ol (7), and (Z)-2-hexenyl β-Dglucopyranoside (8) were isolated from the methanol extract of the Antidesma hainanensis leaves. Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported data. This is the first report of these compounds from Euphorbiaceae family. Keywords. Antidesma hainanensis, Euphorbiaceae, megastigman. 1. INTRODUCTION voucher specimen was deposited at Institute of Marine Biochemistry, VAST. Antidesma is a genus of tropical plants belonging to Euphorbiaceae family and comprises about 100 species in the world and 29 species in Vietnam [1]. The study of the chemical composition showed this genus contains alkaloids, coumarinolignans, megastigmanes, lignan glucosides, benzopyranones, ferulic acid, and particularly is rich in polyphenols, in addition to oil. Biological activity of this genus and pure substances extracted from this genus has been studied, such as antifungal, cytotoxic, and antioxidant activities [2]. However, no public announcement about the chemical composition and biological activity of A. hainanensis has been reported up to now. As .
