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Objectives: Adipose tissue-derived hormones are associated with metabolic disorders including type 2 diabetes mellitus (T2DM). This study investigated clinical parameters and the levels of leptin cytokine in patients with T2DM with or without overweight/obese. | Journal of military pharmaco-medicine No7-2016 INVESTIGATION OF PLASMA LEPTIN LEVEL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Nguyen Van Hoan*; Nguyen Thanh Binh**; Doan Van De*; Nguyen Linh Toan*** SUMMARY Objectives: Adipose tissue-derived hormones are associated with metabolic disorders including type 2 diabetes mellitus (T2DM). This study investigated clinical parameters and the levels of leptin cytokine in patients with T2DM with or without overweight/obese. Materials and methods: Based on body mass index (BMI), 130 patients with T2DM were divided either as overweight/obese or non-overweight/non-obese subjects. 125 overweight/obese and nonoverweight/non-obese individuals devoid of T2DM were included as healthy controls. The leptin levels were measured in the plasma samples in all study subjects by ELISA and clinical parameters. Results: The leptin levels were significantly lower in patients with T2DM compared to controls ([1202.75 pg/ml median vs. 1715.4 pg/ml], p = 0.05). The leptin levels were increased in overweight/obese T2DM patients and in overweight/obese healthy subjects compared to without overweight/obese T2DM patients and healthy induviduals (p 0.05 92.12 ± 47.35 78.60 ± 38.79 > 0.05 < 0.0001 (*) Comparison between type 2 diabetes mellitus and non-diabetes mellitus. The mean age of the patients with T2DM was higher than control individuals (without T2DM) (p < 0.05), while there was no difference in mean age between the patients with overweight T2DM and non-overweight T2DM. The proportion of male patients with T2DM was higher than the control group (p = 0.03). The levels of fasting glucose, triglycerides were significantly higher in the patients with T2DM compared to control individuals (p < 0.05). The levels of insulin and homeostasis model assessment insulin resistance (HOMA-RI) were significantly higher in the patients with T2DM compared to control individuals (p < 0.001). In contrast, the levels of quantitative insulin sensitivity check .
