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Objectives: To optimize formulation of curcumin solid dispersion (CSD). Methods: Prepare curcumin solid dispersion using spray drying method and apply Modde 7.0 software to design the experiments and optimize the formulations. | Journal of military pharmaco-medicine No7-2016 APPLICATION OF MODDE 7.0 SOFTWARE TO OPTIMIZE FORMULATION OF CURCUMIN SOLID DISPERSION USING SPRAY DRYING METHOD Vu Binh Duong*; Nguyen Hai Dang Trieu*; Pham Van Hien* Trinh Thanh Hung**; Nguyen Trong Diep*; Pham Thi Thanh Huong* SUMMARY Objectives: To optimize formulation of curcumin solid dispersion (CSD). Methods: Prepare curcumin solid dispersion using spray drying method and apply Modde 7.0 software to design the experiments and optimize the formulations. Results: The optimal formulation to prepare curcumin solid dispersion system using spray drying method including: ratio of curcumin: PVP K30 (1:8.8, w/w) composed 0.76% of lutrol F127 and 3.85% aerosil. With this optimal formulation, the solubility of curcumin was 6942.47g/L and the dissolution reached 100% in period of 30 minutes. Conclusion: The optimal formulation for preparing curcumin solid dispersion system using spray drying method was established that is potential to enhance bioavaibility of this active component. * Key words: Curcumin solid dispersion; Spray drying method; Optimization; Experimental design. INTRODUCTION Curcumin that is a polyphenol extracted from Radix of Curcuma longa L. owns valuable bioactivities as anti-inflammation, antioxidant, inhibition of cancer cell, antimicrobial [2, 3]. In according to biopharmaceutical classification, this compound belongs to IV class with less solubility and penetration [6]. In fact, curcumin is nearly insoluble in water, less absorption and fast elimination so its bioavaibility is too low. O HO OCH3 curcumin MATERIALS AND METHODS 1. Materials and instruments. O H3CO we prepared solid dispersion using spray drying method with carrier as PVP K30. It found that solubility and dissolution were enhanced significantly. Based on this research, we continuously optimized compositions of formulation using experimental design software. In this publication, we informed the result of formulation optimization
